What is Preimplantation Genetic Testing for Monogenic (PGT-M)?
PGT-M is a treatment that checks embryos for specific genetic conditions. It examines their genes and chromosomes.
If you need to test embryos in a lab, you will have to undergo IVF, even if you and your partner are not facing fertility issues. After testing to ensure the embryo does not carry the condition, it will be placed back in your womb to grow. Previously, doctors usually transferred the embryo two to six days after it was created, known as a fresh embryo transfer. It is more common to freeze the embryo and transfer it later.
Which genetic conditions can be tested using PGT-M?
You can use PGT-M to test for many genetic conditions if a specific gene is known to cause the condition. However, testing is only allowed if the authority has reviewed it and determined that it meets legal requirements regarding the risk of passing on the condition and the seriousness of symptoms in someone affected by the genetic issue being tested.
Why should PGT- M be done?
This test helps couples in conceiving a healthy pregnancy. The procedure is done before a female becomes pregnant. PGT- M:
- It studies the DNA of every embryo
- Identifies the good embryo
- Helps a doctor in choosing which of the embryos is good enough for transfer
Who must undergo PGT-M?
PGT-M is advocated for
Fertile couples who have a genetic history of a hereditary disease
Couples with a history of severe monogenic or single-gene disorder disorders (some common examples: Cystic Fibrosis, Spinal Muscular Dystrophies or SMA, Huntington’s disease)
What are the requirements for performing PGT-M?
A genetic disorder leads to an abnormal gene function by an abnormal DNA sequence (or mutation).
A set-up test is required for a PGT-M. Every couple has an individual probe used to execute the test on embryos.
Blood samples are obtained from the couple or their relatives to construct the probe.
Who may be eligible for PGT-M or PGT-SR?
Your physician may refer you for PGT-M or PGT-SR if:
- You have lost previous pregnancies due to a severe genetic disorder
- You already have a child with a severe genetic disorder, and you would like not to repeat the experience
- You have a family history of a severe genetic disorder
- Do you have a family history of chromosome issues?
- Have you experienced repeated miscarriages because of chromosomal problems?
How and when is PGT-M performed?
This procedure involves testing embryos developed through IVF and choosing and transferring those with the appropriate amount of chromosomal material.
An embryo biopsy is performed once it has been grown in culture for almost five days and reaches the developmental stage called the blastocyst stage, which comprises hundreds of cells.
The biopsy removes 5 to 7 cells of the external layer of the embryo, called the trophectoderm, without touching the inner cell mass that develops the fetus.
Analysis of the genetic material of the embryo is then performed.
Embryos are cryopreserved after biopsy. In the subsequent cycle, based on the results from PGT-M, the adequate embryos are thawed and transferred into the patient’s uterus.
Is PGT-M safe to perform?
PGT-M is safe. An experienced embryologist must handle the treatment. Normal embryo development is observed after the biopsy.
Why Tender Palm IVF & Fertility Center for Preimplantation Genetic Testing for Monogenic (PGT-M) in Lucknow, India?
Tender Palm IVF & Fertility Center offers advanced Preimplantation Genetic Testing for Monogenic (PGT-M) in Lucknow, India to help couples prevent the transmission of inherited genetic diseases. Our expert genetic counselors and embryologists use cutting-edge technology to screen embryos during IVF for specific single-gene disorders such as thalassemia, cystic fibrosis, or sickle cell anemia. We ensure accurate diagnosis, healthy embryo selection, and personalized guidance for couples with known genetic risks, providing hope for a healthy family.