What is Preimplantation Genetic Testing for Aneuploidies (PGTA)?
Preimplantation Genetic Testing for Aneuploidies (PGTA) is an IVF technique used to screen embryos for chromosomal abnormalities before they are implanted. This process involves biopsying cells from embryos, analyzing them for genetic problems, and then selecting the healthiest ones to be transferred to increase the chances of a successful pregnancy.
In what situation is PGTA required?
PGTA may be considered for women who are aged over 37 and who have had multiple pregnancy losses or unsuccessful IVF transfers; for those patients who have a chromosome disorder in the family, PGTA helps to identify euploid embryos, thereby avoiding transferring aneuploid ones.
What is the procedure for preimplantation genetic testing for aneuploidies (PGTA)?
The preimplantation genetic diagnosis test is done on an early fetus before it is put into the uterus. This is usually done when one of the couples has had a lot of losses or genetic problems in the past. This process lowers or gets rid of the chance of getting genetic traits and chromosomal issues that you don’t want.
Before they do the procedure, fertility doctors will look at the patient’s genetic history and other things that might affect fertility. This makes it more likely that you will have a healthy child.
The following are parts of the preimplantation genetic testing process:
- PGS (Preimplantation Genetic Screening): To do this, the eggs must be checked for chromosomal problems. PGS helps ensure that there are 23 pairs of chromosomes and no extra or missing ones.
- PGD (Preimplantation Genetic Diagnosis): As part of PGD, embryos are checked for genetic diseases or single gene flaws already found in one or both parents.
What steps are involved in the PGTA procedure?
The PGTA involves the following steps:
Medical Diagnosis
Your appointments with highly experienced fertility doctors will involve discussing why you require PGT-A. Once your DNA is analyzed to determine whether you and your partner carry the gene responsible for the disease, the doctor will give a clinical diagnosis.
Genetic Counselling
The genetic counsellor you were recommended will discuss the details of the disease, your genetic susceptibility, and how probable it is to occur in pregnancy. During the therapy session, the counsellor will discuss the possible outcomes and effects of PGT.
Preparing for PGT workup and feasibility test
After your test results and permission, the PGT laboratory will determine if PGT-A is appropriate for your situation. While waiting for permission to prepare for the PGT workup, you and your partner must provide blood samples to the clinic’s testing lab. The IVF cycle may start after the workup processes are completed.
What are the benefits of PGTA?
PGTA has many advantages over families undergoing IVF, especially as this test selects embryos without any chromosomal problems or specific genetic mutations, which increases the chances of healthy pregnancy and good implantation. This not only helps in increasing the success rate of IVF but also brings down the mental and monetary stress associated with multiple cycles or failure after a pregnancy. PGTM provides families with a history of genetic disorders the opportunity to prevent these problems from being passed on to their children. Generally, PGTA provides families with useful knowledge that helps them make better reproductive decisions and increases their chances of having a healthy baby.
What are the risks associated with the PGTA procedure?
Drawbacks and issues with the PGTA procedure include the following:
- As PGS and PGD involve In Vitro Fertilisation, there are risks associated with ovarian hyperstimulation syndrome, multiple pregnancies, and a baby that is not normal.
- The chance of developing a pelvic infection, loss, ectopic pregnancy, and other issues increases.
- Biopsy and freeze on the embryo
- A greater percentage of IVF babies born are born premature and have low birth weights.
- These tests prove that there are no healthy embryos to transfer.
- The tests cannot guarantee that the child will always be healthy since not all genetic diseases or problems are found.
Being aware of all the advantages and disadvantages of PGS can make us believe that it is better to apply PGS in assisted reproductive procedures because it increases the possibility that the therapy will succeed.
Is PGT-A safe procedure?
The process is safe. If done right by an experienced embryologist, it will ensure that the embryo grows properly even after the biopsy.
Does PGT-A assesses all genetic diseases?
PGT-A testing can only evaluate the changes in chromosome count and other imbalances of genetic material, including deletions (a part of the chromosome is missing) and duplications (a part of the chromosome is doubled).
Why Tender Palm IVF & Fertility Center for PGT-A (Preimplantation Genetic Testing for Aneuploidies) in Lucknow, India?
Tender Palm IVF & Fertility Center offers advanced Preimplantation Genetic Testing for Aneuploidies in Lucknow, India to improve IVF success rates and reduce the risk of genetic disorders. Our experienced fertility specialists use cutting-edge NGS (Next Generation Sequencing) technology to screen embryos for chromosomal abnormalities before implantation. This ensures only chromosomally normal embryos are selected, increasing the chances of a healthy pregnancy. We offer personalized IVF plans, genetic counseling, and transparent care in a compassionate environment.